Description

6-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting central nervous system disorders. It is primarily sought after by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spirocyclic structure.
• API Development: Serves as a critical precursor in the development of Active Pharmaceutical Ingredients (APIs) with complex molecular architectures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Biochemical Tool Compound: May be utilized in preclinical research as a probe to study specific biological pathways and receptor interactions.

Basic Information

Product Name	6-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride
CAS No.	1774904-83-4
Molecular Formula	C13H14ClFN2O
Molecular Weight	268.71 g/mol
Synonyms	6-Fluoro-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one hydrochloride; 6-Fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine] hydrochloride; 6-Fluoro-1,2-dihydrospiro[3H-indole-3,4'-piperidine]-2-one HCl; 6-Fluoro-2-oxospiro[indoline-3,4'-piperidine] hydrochloride; 1774904-83-4; Spiro[indole-3,4'-piperidine]-2-one, 6-fluoro-1,2-dihydro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.