Description

1-[2-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and trifluoromethylbenzyl moiety. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl and amine functionalities.
• API Development: Serves as a critical precursor in the development and scale-up of new active pharmaceutical ingredients.
• Biochemical Tool Compound: May be utilized in vitro to study biological pathways and receptor interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Used in university and institutional labs for advanced organic synthesis and pharmacological studies.

Basic Information

Product Name	1-[2-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride
CAS No.	1774896-59-1
Molecular Formula	C13H18Cl2F3N2
Molecular Weight	333.20 g/mol
Synonyms	1-[(2-Trifluoromethyl)phenyl]methyl-4-piperidinamine dihydrochloride; 4-Amino-1-[(2-trifluoromethyl)benzyl]piperidine dihydrochloride; 1-(2-(Trifluoromethyl)benzyl)piperidin-4-amine dihydrochloride; 1-[(2-Trifluoromethyl)benzyl]-4-aminopiperidine dihydrochloride; α-(2-Trifluoromethylphenyl)-4-piperidinemethanamine dihydrochloride; 4-Amino-1-[(α,α,α-trifluoro-o-tolyl)methyl]piperidine dihydrochloride; 1-(2-Trifluoromethylbenzyl)piperidin-4-ylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-[2-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.