Description

1,8-Naphthyridine, 2-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its chiral oxazoline-substituted naphthyridine core structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis to discover new bioactive compounds.
• Asymmetric Synthesis: The chiral oxazoline moiety acts as a directing group or ligand precursor in catalytic asymmetric transformations.
• Chemical Biology Probes: Employed in the development of chemical probes to study enzyme function and biological pathways.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Academic Research: A valuable compound for university and institutional research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1,8-Naphthyridine, 2-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-
CAS No.	1772625-41-8
Molecular Formula	C₁₈H₁₇N₃O
Molecular Weight	291.35 g/mol
Synonyms	(4S)-4-(Benzyl)-4,5-dihydro-2-(1,8-naphthyridin-2-yl)oxazole; 2-[(4S)-4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl]-1,8-naphthyridine; (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)-1,8-naphthyridine; (S)-4-Benzyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole; 1,8-Naphthyridine, 2-(4,5-dihydro-4-(phenylmethyl)-2-oxazolyl)-, (4S)-; Chiral Naphthyridine-Oxazoline Ligand Precursor; (S)-2-(1,8-Naphthyridin-2-yl)-4-benzyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine, 2-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.