Description

(S,E)-2-(3-((tert-Butyldimethylsilyl)Oxy)-3-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)Propyl)Benzoic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral and olefinic structure. This compound is of critical importance for its role in the synthesis of novel therapeutic agents, particularly within medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions focused on drug discovery programs targeting specific disease pathways.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of potential drug candidates, especially those targeting specific receptor interactions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the efficacy and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant scale.
• Academic & Institutional R&D: Employed in university and research institute laboratories for investigating new synthetic methodologies and biological targets.
• Custom Synthesis: Starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research projects.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	(S,E)-2-(3-((tert-Butyldimethylsilyl)Oxy)-3-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)Propyl)Benzoic Acid Methyl Ester
CAS No.	1772578-77-4
Molecular Formula	C34H38ClNO3Si
Molecular Weight	572.21 g/mol
Synonyms	(S,E)-Methyl 2-[3-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[(tert-butyldimethylsilyl)oxy]propyl]benzoate; (S,E)-2-(3-((tert-Butyldimethylsilyl)oxy)-3-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoic acid methyl ester; Methyl (S,E)-2-(3-((tert-butyldimethylsilyl)oxy)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate; TBS-protected chloroquinolinyl intermediate; (S,E)-TBDMS ether of chloroquinoline vinyl benzyl benzoate
EINECS	Contact for details

Quality Control

Our production of (S,E)-2-(3-((tert-Butyldimethylsilyl)Oxy)-3-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)Propyl)Benzoic Acid Methyl Ester adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure high chemical and isomeric purity. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.