Description

6-Bromo-2-(Trifluoromethyl)Benzo[B]Thiophene is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound matters for its role as a critical synthetic intermediate in the development of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging the bioactivity of the benzothiophene core.
• Material Science Research: Serves as a building block for organic semiconductors, liquid crystals, and other functional materials due to its electron-deficient properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes and enzyme inhibition.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry: The trifluoromethyl group is a valuable motif for modulating lipophilicity, metabolic stability, and binding affinity in lead optimization.

Basic Information

Product Name	6-Bromo-2-(Trifluoromethyl)Benzo[B]Thiophene
CAS No.	1709825-02-4
Molecular Formula	C9H4BrF3S
Molecular Weight	281.09 g/mol
Synonyms	6-Bromo-2-(trifluoromethyl)-1-benzothiophene; 2-(Trifluoromethyl)-6-bromobenzothiophene; 6-Bromo-2-trifluoromethylbenzo[b]thiophene; Benzo[b]thiophene, 6-bromo-2-(trifluoromethyl)-; 1709825-02-4; 6-Br-2-CF3-Benzothiophene
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(Trifluoromethyl)Benzo[B]Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of high-purity material for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.