Description

tert-Butyl2-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic triaza scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its structural complexity which enables the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spirocyclic triaza core.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors, a major class of oncology drugs.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological processes and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Item	Details
Product Name	tert-Butyl2-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate
CAS No.	1707713-85-6
Molecular Formula	C21H27FN4O3
Molecular Weight	402.47 g/mol
Synonyms	tert-Butyl 2-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate; 1,3,8-Triazaspiro[4.5]dec-1-ene-8-carboxylic acid, 2-(4-fluorophenyl)-4-oxo-, 1,1-dimethylethyl ester; 1707713-85-6; 8-Boc-2-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene; tert-Butyl 2-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate; BOC-protected spirocyclic triaza intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl2-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.