Description

1-[4-(Trifluoromethyl)Phenyl]-1H-Imidazole-5-Carboxylic Acid is a high-value trifluoromethylated heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for introducing both the imidazole pharmacophore and the metabolically stable trifluoromethyl group into target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other biologically relevant small molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of potential drug candidates, particularly in oncology and inflammation.
• Agrochemical Synthesis: Used in creating novel active ingredients for crop protection with enhanced properties.
• Chemical Biology Probe Development: Serves as a core structure for designing enzyme inhibitors and molecular probes to study biological pathways.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this precise chemical architecture.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Phenyl]-1H-Imidazole-5-Carboxylic Acid
CAS No.	1707361-69-0
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-1H-imidazole-5-carboxylic acid; 5-Imidazolecarboxylic acid, 1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethylphenyl)-1H-imidazole-5-carboxylic acid; 1-(4-(Trifluoromethyl)phenyl)-1H-imidazole-5-carboxylic acid; 1-(α,α,α-Trifluoro-p-tolyl)-1H-imidazole-5-carboxylic acid; 1707361-69-0; 1-(4-Trifluoromethylphenyl)imidazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Phenyl]-1H-Imidazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grade meets high-purity requirements for research and development; custom purities and specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.