Description

(4-Chloro-3-(4-(2-Hydroxyethyl)Piperazine-1-Carbonyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling with a piperazine-hydroxyl moiety that offers excellent solubility and potential for further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical industry developing targeted therapies, particularly in the synthesis of complex small molecule APIs and PROTACs (Proteolysis Targeting Chimeras).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted oncology treatments.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds for constructing biaryl structures, a common motif in medicinal chemistry.
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a versatile linker component connecting an E3 ligase ligand to a target protein ligand.
• Chemical Biology Probe Synthesis: Enables the creation of molecules for studying protein function and cellular pathways.
• Material Science Research: Potential building block for advanced organic frameworks or polymers with specific binding properties.
• Agrochemical Intermediate: Used in the research and development of new, more effective crop protection agents.

Basic Information

Product Name	(4-Chloro-3-(4-(2-Hydroxyethyl)Piperazine-1-Carbonyl)Phenyl)Boronic Acid
CAS No.	1704080-40-9
Molecular Formula	C13H18BClN2O4
Molecular Weight	312.56 g/mol
Synonyms	4-Chloro-3-[4-(2-hydroxyethyl)piperazine-1-carbonyl]benzeneboronic acid; 2-[4-[(4-Chloro-3-boronophenyl)carbonyl]piperazin-1-yl]ethanol; (4-Chloro-3-{[4-(2-hydroxyethyl)piperazine-1-yl]carbonyl}phenyl)boronic acid; B-[4-Chloro-3-[[4-(2-hydroxyethyl)-1-piperazinyl]carbonyl]phenyl]boronic acid; CAS 1704080-40-9; Boronic acid, B-[4-chloro-3-[[4-(2-hydroxyethyl)-1-piperazinyl]carbonyl]phenyl]-; 1704080-40-9
EINECS	Contact for details

Quality Control

Our (4-Chloro-3-(4-(2-Hydroxyethyl)Piperazine-1-Carbonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.