Description

6-Fluoroindoline-5-Carbonitrile is a high-value, fluorinated heterocyclic building block of significant interest in modern synthetic chemistry. Its core structure, featuring both a fluorine substituent and a nitrile group on an indoline scaffold, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and modulate the physicochemical properties of lead candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for organic electronic materials and functional dyes, leveraging its electron-deficient aromatic system.
• Chemical Biology Probe Development: Employed in the design of fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	6-Fluoroindoline-5-Carbonitrile
CAS No.	1702230-01-0
Molecular Formula	C9H7FN2
Molecular Weight	162.17 g/mol
Synonyms	5-Cyano-6-fluoroindoline; 6-Fluoro-2,3-dihydro-1H-indole-5-carbonitrile; 6-Fluoro-5-cyanoindoline; 1H-Indole-5-carbonitrile, 6-fluoro-2,3-dihydro-; 6-Fluoroindoline-5-carbonitrile; 1702230-01-0
EINECS	Contact for details

Quality Control

Our 6-Fluoroindoline-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with the standards required for cGMP and ISO-certified production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.