Description

2-Amino-5-Iodo-3-Trifluoromethyl-Benzoic Acid is a high-value, multi-functional aromatic building block featuring a trifluoromethyl group, an iodine substituent, and a carboxylic acid moiety. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients, particularly in the development of targeted therapies and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology, CNS, and anti-infective research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or optical properties.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and target engagement due to the handle provided by the iodine atom for further functionalization.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences industry.

Basic Information

Item	Details
Product Name	2-Amino-5-Iodo-3-Trifluoromethyl-Benzoic Acid
CAS No.	1700636-72-1
Molecular Formula	C8H5F3INO2
Molecular Weight	331.03 g/mol
Synonyms	2-Amino-5-iodo-3-(trifluoromethyl)benzoic acid; 5-Iodo-2-amino-α,α,α-trifluoro-m-toluic acid; Benzoic acid, 2-amino-5-iodo-3-(trifluoromethyl)-; 3-Trifluoromethyl-5-iodoanthranilic acid; 2-Amino-α,α,α-trifluoro-5-iodo-m-toluic acid; 5-Iodo-3-trifluoromethylanthranilic acid
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard offering for this advanced intermediate typically meets a purity specification of ≥97% (HPLC), with options for higher grades (≥98%, ≥99%) available. Identity is confirmed by NMR and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and residual solvent levels is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.