Description

4-Chloro-2-Cyclopropyl-7-Fluoroquinazoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core quinazoline scaffold, strategically functionalized with chloro, cyclopropyl, and fluoro substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates, leveraging its versatile halogenated quinazoline core for further functionalization.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides, where the cyclopropyl and fluoro groups often enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Used in medicinal chemistry to create tool compounds for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic electronic materials due to its rigid, aromatic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	4-Chloro-2-Cyclopropyl-7-Fluoroquinazoline
CAS No.	1699190-56-1
Molecular Formula	C11H7ClFN3
Molecular Weight	235.64 g/mol
Synonyms	7-Fluoro-2-cyclopropyl-4-chloroquinazoline; 4-Chloro-7-fluoro-2-cyclopropylquinazoline; 2-Cyclopropyl-7-fluoro-4-chloroquinazoline; 4-Chloro-2-cyclopropyl-7-fluoro-quinazoline; Quinazoline, 4-chloro-2-cyclopropyl-7-fluoro-; 1699190-56-1; 4-Chloro-7-fluoro-2-cyclopropyl-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Cyclopropyl-7-Fluoroquinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for residual solvent analysis, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.