Description

tert-Butyl 4-(7-Bromo-6-Chloro-8-Fluoroquinazolin-4-Yl)Piperazine-1-Carboxylate is a high-purity, multi-functional heterocyclic building block designed for advanced pharmaceutical research and development. Its complex molecular structure, featuring a halogenated quinazoline core, makes it a critical intermediate for synthesizing targeted kinase inhibitors and other biologically active compounds. This product is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of small molecule kinase inhibitors targeting various oncology and inflammatory pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile piperazine-quinazoline scaffold.
• Process Chemistry Development: Serves as a critical intermediate in scaling up the production of active pharmaceutical ingredients (APIs) for clinical trials and commercial manufacturing.
• Bioconjugation & Probe Synthesis: The reactive halogen atoms and protected amine allow for further functionalization to create chemical probes for biological target identification and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development of novel chemical entities for client projects.

Basic Information

Product Name	tert-Butyl 4-(7-Bromo-6-Chloro-8-Fluoroquinazolin-4-Yl)Piperazine-1-Carboxylate
CAS No.	1698027-20-1
Molecular Formula	C₁₇H₁₉BrClFN₄O₂
Molecular Weight	445.71 g/mol
Synonyms	Boc-4-(7-Bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine; 1-Boc-4-(7-Bromo-6-chloro-8-fluoro-4-quinazolinyl)piperazine; tert-Butyl 4-(7-bromo-6-chloro-8-fluoro-4-quinazolinyl)-1-piperazinecarboxylate; 7-Bromo-6-chloro-8-fluoro-4-(1-piperazinyl)quinazoline 1-Boc derivative; 4-(7-Bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-Quinazoline Intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(7-Bromo-6-Chloro-8-Fluoroquinazolin-4-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.