Description

7-Bromo-6-Methoxyquinazolin-4-Ol is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of small-molecule drug candidates, especially protein kinase inhibitors.
• Oncology Research: Serves as a core scaffold for developing compounds targeting specific cancer pathways.
• Chemical Biology: Used as a molecular probe or tool compound for studying enzyme function and signal transduction mechanisms.
• Agrochemical Development: Potential intermediate for creating novel herbicides or plant growth regulators, leveraging its heterocyclic structure.
• Material Science Research: Can be investigated as a monomer or building block for specialty polymers or organic electronic materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	7-Bromo-6-Methoxyquinazolin-4-Ol
CAS No.	1698027-08-5
Molecular Formula	C9H7BrN2O2
Molecular Weight	255.07 g/mol
Synonyms	4-Hydroxy-7-bromo-6-methoxyquinazoline; 7-Bromo-6-methoxy-4(3H)-quinazolinone; 7-Bromo-6-methoxyquinazolin-4(3H)-one; 4(3H)-Quinazolinone, 7-bromo-6-methoxy-; 7-Bromo-6-methoxy-4-hydroxyquinazoline; 1698027-08-5; 7-Br-6-MeO-quinazolin-4-ol
EINECS	Contact for details

Quality Control

Our 7-Bromo-6-Methoxyquinazolin-4-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.