Description

Phenol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)- is a highly versatile and valuable organoboron building block, specifically a boronic ester derivative of a substituted phenol. This compound is engineered for advanced synthetic chemistry, offering a protected boronic acid functionality that is crucial for modern cross-coupling reactions. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those requiring the trifluoromethoxyphenyl moiety for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the unique phenol-boronate structure introduces specific biological activity.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating advanced organic electronic materials, where its structural components can influence charge transport and luminescent properties.
• Polymer & Specialty Chemical Modification: Employed to introduce functional phenolic and boron-containing groups into polymer backbones or specialty molecules to alter physical and chemical characteristics.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological processes, leveraging the reactivity of the boronic ester group.

Basic Information

Product Name	Phenol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)-
CAS No.	1689502-03-1
Molecular Formula	C13H16BF3O4
Molecular Weight	304.07 g/mol
Synonyms	4-(Trifluoromethoxy)phenylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)phenol; [4-(Trifluoromethoxy)phenyl]boronic acid pinacol ester; 4-(Trifluoromethoxyphenyl)boronic acid pinacol ester; 4-Trifluoromethoxyphenylboronic acid pinacol ester; 4-(Trifluoromethoxy)benzeneboronic acid pinacol ester; PINACOL [4-(TRIFLUOROMETHOXY)PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our Phenol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee the material meets your specific research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.