Description

3-Bromo-7,8-Difluoroquinoline is a high-value, multi-functional halogenated quinoline building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoroquinoline core contributes to biological activity and metabolic stability.
• Material Science Research: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs (Organic Light-Emitting Diodes) and charge-transport materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille), enabling rapid diversification of the quinoline scaffold.
• Fluorinated Compound Libraries: Integral for medicinal chemistry programs focused on exploring the benefits of fluorine incorporation to improve potency, membrane permeability, and metabolic profile.
• Ligand and Catalyst Development: Utilized in the preparation of novel nitrogen-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Bromo-7,8-Difluoroquinoline
CAS No.	1686108-69-9
Molecular Formula	C9H4BrF2N
Molecular Weight	244.04 g/mol
Synonyms	7,8-Difluoro-3-bromoquinoline; Quinoline, 3-bromo-7,8-difluoro-; 3-Bromo-7,8-difluoro-quinoline; 1686108-69-9; 7,8-Difluoro-3-bromo-quinoline; 3-Brom-7,8-difluorchinolin (German); 3-ブロモ-7,8-ジフルオロキノリン (Japanese)
EINECS	Contact for details

Quality Control

Our 3-Bromo-7,8-Difluoroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.