Description

(3Ar,5R,6S,6Ar)-5-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-5-(Hydroxymethyl)-2,2-Dimethyl-6,6A-Dihydro-3Ah-Furo[2,3-D][1,3]-Dioxol-6-Ol is a high-purity, stereochemically defined carbohydrate derivative and protected sugar intermediate. This compound is critical for synthetic chemists requiring precise control over molecular architecture in complex organic synthesis. It serves as a key chiral building block for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing nucleoside analogs, antiviral agents, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A vital chiral precursor in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Glycochemistry Research: Used in the study and synthesis of complex carbohydrates, glycoconjugates, and glycomimetics for drug discovery.
• Asymmetric Synthesis: Serves as a starting material or intermediate for constructing stereocenters in natural product total synthesis and medicinal chemistry campaigns.
• Process Chemistry Development: Employed in scaling up routes to active pharmaceutical ingredients (APIs) that require this specific protected sugar scaffold.
• Bioconjugation & Probe Development: Useful for modifying biomolecules or creating labeled probes for biochemical and diagnostic applications.
• Fine Chemical Production: Acts as a specialized intermediate for manufacturing high-value, low-volume chemicals with specific stereochemical requirements.

Basic Information

Item	Details
Product Name	(3Ar,5R,6S,6Ar)-5-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-5-(Hydroxymethyl)-2,2-Dimethyl-6,6A-Dihydro-3Ah-Furo[2,3-D][1,3]-Dioxol-6-Ol
CAS No.	1646857-53-5
Molecular Formula	C15H24O7
Molecular Weight	316.35 g/mol
Synonyms	1,2:5,6-Di-O-isopropylidene-α-D-allofuranose derivative; Protected D-Allose derivative; (3aR,5R,6S,6aR)-5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol; Diacetone allofuranose intermediate; D-Allofuranose, 1,2:5,6-di-O-isopropylidene-, (R)-; Chiral furanodioxolane sugar alcohol.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under strict quality management systems. We ensure high chiral purity and chemical integrity through comprehensive analytical methods including HPLC, NMR, and optical rotation. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and stereochemical composition. Our quality commitment supports cGMP and ISO standards for reliable integration into regulated research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Optical Rotation	Provided on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.