Description

6-Bromo-3,4-difluoro-2-nitrophenol is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents on a phenolic core, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of halogenated nitrophenols.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments due to its nitrophenol backbone and halogen substituents.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create biaryl structures.
• Fluorine Chemistry Building Block: The difluoro motif is valuable for introducing fluorine atoms into target molecules to modulate lipophilicity, metabolic stability, and bioavailability.

Basic Information

Product Name	6-Bromo-3,4-difluoro-2-nitrophenol
CAS No.	1644281-87-7
Molecular Formula	C6H2BrF2NO3
Molecular Weight	253.99 g/mol
Synonyms	2-Nitro-6-bromo-3,4-difluorophenol; 3,4-Difluoro-6-bromo-2-nitrophenol; Phenol, 6-bromo-3,4-difluoro-2-nitro-; 6-Bromo-3,4-difluoro-2-nitro-1-hydroxybenzene; 2-Bromo-4,5-difluoro-6-nitrophenol
EINECS	Contact for details

Quality Control

Our 6-Bromo-3,4-difluoro-2-nitrophenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.