Description

4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butan-1-Aminium Trifluoroacetate is a high-purity chemical intermediate featuring a maleimide-reactive group and a primary ammonium moiety, making it a versatile building block for bioconjugation and advanced material synthesis. Its primary value lies in enabling the site-specific modification of biomolecules and polymers under mild aqueous conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotech, and diagnostics sectors developing targeted therapeutics, antibody-drug conjugates (ADCs), and functionalized surfaces.

Application

• Bioconjugation Reagent: Key intermediate for the synthesis of heterobifunctional crosslinkers used to attach drugs, fluorophores, or other payloads to antibodies, proteins, or peptides.
• Antibody-Drug Conjugate (ADC) Development: Serves as a critical precursor for constructing linker-payload complexes that target cancer cells.
• Polymer Functionalization: Used to introduce reactive maleimide groups onto polymer backbones or nanoparticles for subsequent coupling with thiol-containing molecules.
• Surface Modification: Enables the creation of maleimide-activated surfaces on biosensors, microarrays, and chromatography media for immobilizing biomolecules.
• Peptide Synthesis: Acts as a protected or activated form of a lysine-like side chain for introducing specific functionality during solid-phase peptide synthesis (SPPS).
• Diagnostic Probe Synthesis: Facilitates the production of labeled probes and imaging agents for in vitro and in vivo diagnostics.

Basic Information

Product Name	4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butan-1-Aminium Trifluoroacetate
CAS No.	1639876-58-6
Molecular Formula	C10H13F3N2O4
Molecular Weight	282.22 g/mol
Synonyms	4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butan-1-aminium trifluoroacetate; 4-Maleimidobutylammonium trifluoroacetate; 1-(4-Aminobutyl)-1H-pyrrole-2,5-dione trifluoroacetate; 4-(Maleimido)butylamine TFA salt; 4-Maleimidobutan-1-aminium trifluoroacetate; Maleimide-PEG3-amine TFA salt precursor; N-(4-Aminobutyl)maleimide trifluoroacetate; TFA salt of 4-Maleimidobutylamine
EINECS	Contact for details

Quality Control

Our 4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butan-1-Aminium Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications in GMP and cGMP environments, and we can tailor specifications to meet your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.