Description

3-(Difluoromethoxy)Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant utility in modern drug discovery. This compound is valued for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique difluoromethoxy-pyrrolidine scaffold.
• API Synthesis: Incorporated into the final structure of active pharmaceutical ingredients requiring a fluorinated pyrrolidine moiety for enhanced metabolic stability and bioavailability.
• Preclinical Development: Serves as a critical material for producing batches of candidate compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.
• Chemical Library Synthesis: Used to create diverse screening libraries for high-throughput screening against novel biological targets.

Basic Information

Product Name	3-(Difluoromethoxy)Pyrrolidine Hydrochloride
CAS No.	1638772-00-5
Molecular Formula	C5H10F2NO • HCl
Molecular Weight	185.60 g/mol
Synonyms	3-(Difluoromethoxy)pyrrolidine HCl; Pyrrolidine, 3-(difluoromethoxy)-, hydrochloride; 3-(Difluoromethoxy)-1-azacyclopentane hydrochloride; 1-Azacyclopentane-3-methanol, α,α-difluoro-, hydrochloride; 1638772-00-5; 3-Difluoromethoxy-pyrrolidine hydrochloride; 3-(Difluoromethoxo)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.