Description

(6,6-Difluorospiro[3.3]heptan-2-yl)methanamine hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated scaffold. This compound matters as a critical building block for medicinal chemistry, enabling the development of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for the synthesis of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Medicinal Chemistry Building Block: Used to introduce the rigid, three-dimensional spiro[3.3]heptane core and fluorine atoms into lead compounds to optimize their potency, selectivity, and pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the difluorinated spirocyclic structure.
• Ligand and Catalyst Development: The amine functionality allows for its use in creating novel chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of specialty monomers for advanced polymers with specific thermal or chemical resistance properties.

Basic Information

Product Name	(6,6-Difluorospiro[3.3]heptan-2-yl)methanamine Hydrochloride
CAS No.	1638765-23-7
Molecular Formula	C8H14ClF2N
Molecular Weight	197.65 g/mol
Synonyms	2-(Aminomethyl)-6,6-difluorospiro[3.3]heptane hydrochloride; 6,6-Difluoro-2-spiro[3.3]heptanemethanamine hydrochloride; (6,6-Difluoro-2-spiro[3.3]heptanyl)methylamine hydrochloride; 2-(Aminomethyl)-6,6-difluorospiro[3.3]heptane HCl; 6,6-Difluorospiro[3.3]heptane-2-methanamine hydrochloride; 2-(Aminomethyl)-6,6-difluoro-spiro[3.3]heptane hydrochloride
EINECS	Contact for details

Quality Control

Our (6,6-Difluorospiro[3.3]heptan-2-yl)methanamine hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.