Description

tert-Butyl(3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate is a specialized, high-value building block featuring the unique and rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound is critical for medicinal chemistry research, enabling the synthesis of novel drug candidates with improved metabolic stability and physicochemical properties. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Bioisostere Development: The BCP core acts as a highly effective, three-dimensional bioisostere for phenyl rings or tert-butyl groups, enhancing drug-like properties such as solubility and lipophilicity.
• Peptidomimetics & PROTACs: Used in constructing advanced molecular architectures like peptidomimetics and proteolysis-targeting chimeras (PROTACs) due to its amine-protected functional handle.
• Agrochemical Research: Employed in the discovery of novel agrochemicals where the BCP motif can confer stability and novel modes of action.
• Material Science: Potential applications in creating novel polymers and advanced materials with unique structural properties derived from the strained cage structure.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl(3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate
CAS No.	1638765-05-5
Molecular Formula	C12H21NO2
Molecular Weight	211.30 g/mol
Synonyms	1-Boc-3-(aminomethyl)bicyclo[1.1.1]pentane; BOC-Protected 3-(Aminomethyl)bicyclo[1.1.1]pentane; tert-Butyl N-[3-(aminomethyl)bicyclo[1.1.1]pentan-1-yl]carbamate; 3-(Aminomethyl)bicyclo[1.1.1]pentane-1-carboxylic acid tert-butyl amide; BCP-NH-Boc; 1-N-Boc-3-aminomethylbicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-carboxamide, N-(aminomethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl(3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.