Description

3,3-Difluoro-4-Methoxypyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated pyrrolidine scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of therapeutics, particularly in areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting protease and kinase enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorine-substituted pyrrolidine core, which can enhance metabolic stability and bioavailability.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Bioconjugation & Probe Synthesis: The amine functionality, protected as the hydrochloride salt, makes it suitable for creating chemical probes or conjugates for biological testing and diagnostic applications.
• Agrochemical Research: Potential application as an intermediate in the development of new generation fluorinated agrochemicals.

Basic Information

Product Name	3,3-Difluoro-4-Methoxypyrrolidine Hydrochloride
CAS No.	1638764-85-8
Molecular Formula	C5H10F2NO • HCl
Molecular Weight	185.60 g/mol (Free base: 150.14 g/mol)
Synonyms	4-Methoxy-3,3-difluoropyrrolidine hydrochloride; 3,3-Difluoro-4-methoxy-pyrrolidine HCl; 3,3-Difluoro-4-methoxypyrrolidine HCl; Pyrrolidine, 3,3-difluoro-4-methoxy-, hydrochloride (1:1); 3,3-Difluoro-4-methoxypyrrolidine Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-4-Methoxypyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.