Description

2,2-Difluorocyclobutan-1-Amine Hydrochloride is a high-purity, fluorinated cyclobutylamine hydrochloride salt, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a strained cyclobutane ring and fluorine substituents, makes it invaluable for modulating the physicochemical properties and metabolic stability of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel small-molecule drugs, particularly in areas like protease inhibitors and kinase modulators.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for specialty polymers and advanced materials requiring fluorinated components.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2,2-Difluorocyclobutan-1-Amine Hydrochloride
CAS No.	1638761-45-1
Molecular Formula	C4H8ClF2N
Molecular Weight	143.56 g/mol
Synonyms	2,2-Difluorocyclobutanamine Hydrochloride; 1-Amino-2,2-difluorocyclobutane Hydrochloride; (1-Amino-2,2-difluorocyclobutyl)hydrochloride; 2,2-Difluorocyclobutan-1-amine HCl; 2,2-Difluoro-1-aminocyclobutane Hydrochloride; 2,2-Difluorocyclobutylamine Hydrochloride; 1-Amino-2,2-difluorocyclobutane HCl
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.