Description

Methyl 2-Methylazetidine-3-Carboxylate Hydrochloride is a high-purity, protected azetidine building block essential for advanced pharmaceutical and agrochemical research. This compound serves as a critical chiral intermediate for the synthesis of novel bioactive molecules, enabling the exploration of constrained ring systems. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used as a building block for creating new active ingredients with potential herbicidal, fungicidal, or insecticidal properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Peptidomimetics: The azetidine ring serves as a constrained scaffold to mimic peptide structures, enhancing metabolic stability and bioavailability.
• Ligand Development: Useful in the preparation of specialized ligands for catalysis and materials science applications.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Methyl 2-Methylazetidine-3-Carboxylate Hydrochloride
CAS No.	1638761-38-2
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	Methyl 2-methylazetidine-3-carboxylate hydrochloride; 2-Methylazetidine-3-carboxylic acid methyl ester hydrochloride; 3-Carbomethoxy-2-methylazetidine hydrochloride; Methyl (2-methylazetidin-3-yl)carboxylate hydrochloride; Azetidine-3-carboxylic acid, 2-methyl-, methyl ester, hydrochloride; 1638761-38-2; 2-Methyl-azetidine-3-carboxylic acid methyl ester HCl
EINECS	Contact for details

Quality Control

Our Methyl 2-Methylazetidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.