Description

(1R)-2,2-Difluorocyclohexan-1-Amine Hydrochloride CAS NO 1638744-85-0 is a high-purity, chiral amine hydrochloride salt featuring a difluorinated cyclohexane backbone. This compound is a critical pharmaceutical intermediate and chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for small molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for creating advanced, fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Organofluorine Chemistry Research: Serves as a valuable substrate for studying the effects of fluorine substitution on molecular conformation and reactivity.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Precursor: Potential use in the development of specialty polymers and advanced materials where fluorine incorporation is desired.

Basic Information

Item	Details
Product Name	(1R)-2,2-Difluorocyclohexan-1-Amine Hydrochloride
CAS No.	1638744-85-0
Molecular Formula	C6H12ClF2N
Molecular Weight	183.62 g/mol
Synonyms	(1R)-2,2-Difluorocyclohexylamine hydrochloride; (R)-2,2-Difluorocyclohexanamine hydrochloride; (1R)-2,2-Difluorocyclohexanamine HCl; (R)-2,2-Difluorocyclohexan-1-amine hydrochloride; 2,2-Difluorocyclohexanamine hydrochloride, (1R)-; (1R,2R)-2,2-Difluorocyclohexan-1-amine hydrochloride (if stereochemistry is trans); trans-2,2-Difluorocyclohexan-1-amine hydrochloride (R,R)-; (R)-trans-2,2-Difluorocyclohexylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-2,2-Difluorocyclohexan-1-Amine Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, to ensure it meets stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.