Description

(1S)-2,2-Difluorocyclohexan-1-Amine Hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (1S)-enantiomer. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients. The precise stereochemistry and fluorine substitution pattern make it a key synthon for medicinal chemistry programs requiring specific bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in CNS and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the difluorocyclohexyl moiety imparts desired biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Asymmetric Synthesis: Employed as a chiral amine source or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Fluorinated Compound Development: Integral for creating molecules where fluorine atoms are used to modulate lipophilicity, metabolic stability, and binding affinity.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	(1S)-2,2-Difluorocyclohexan-1-Amine Hydrochloride
CAS No.	1638744-12-3
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	(1S)-2,2-Difluorocyclohexylamine hydrochloride; (S)-2,2-Difluorocyclohexanamine hydrochloride; (1S)-2,2-Difluoro-1-cyclohexanamine hydrochloride; (S)-2,2-Difluoro-1-cyclohexanamine HCl; (1S)-2,2-Difluorocyclohexan-1-aminium chloride; (S)-2,2-Difluorocyclohexan-1-amine HCl; (S)-2,2-Difluorocyclohexanamine HCl salt; (1S)-2,2-Difluorocyclohexanamine hydrochloride
EINECS	Contact for details

Quality Control

Our (1S)-2,2-Difluorocyclohexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.