Description

Methyl (3R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hcl is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound is critical for research and development in medicinal chemistry, particularly for constructing complex molecules with specific stereochemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Asymmetric Synthesis: Serves as a precursor for the preparation of more complex tetrahydroisoquinoline derivatives with defined stereocenters.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.
• Academic Research: Employed in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	Methyl (3R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride
CAS No.	1638668-14-0
Molecular Formula	C11H13BrClNO2
Molecular Weight	306.58 g/mol
Synonyms	(3R)-5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid methyl ester hydrochloride; Methyl (R)-5-bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; 5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester (R)-hydrochloride; (R)-Methyl 5-bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate HCl; 1638668-14-0; 5-Bromo-TIQ-3-carboxylate methyl ester HCl (R-isomer)
EINECS	Contact for details

Quality Control

Our Methyl (3R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.