Description

Spiro[Cyclopropane-1,3'-Pyrrolo[2,3-C]Pyridin]-2'(1'H)-One CAS NO 1637752-28-3 is a high-value, spirocyclic organic compound featuring a fused pyrrolopyridine core, serving as a critical advanced intermediate in modern pharmaceutical research and development. Its unique three-dimensional, rigid scaffold is engineered to enhance binding affinity and selectivity, making it a powerful building block for medicinal chemists. This compound is primarily targeted for use in the discovery and synthesis of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates targeting protein-protein interactions.
• Kinase Inhibitor Development: Core scaffold in the research and development of potent and selective kinase inhibitors for oncology applications.
• CNS Drug Discovery: Used in constructing complex molecules aimed at neurological targets due to its ability to cross the blood-brain barrier.
• Chemical Biology Probes: Serves as a starting material for creating specialized probes to study enzyme function and cellular pathways.
• Fragment-Based Drug Design (FBDD): An ideal, three-dimensional fragment for screening and optimizing lead compounds in early-stage discovery.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization during the transition from laboratory to pilot-scale synthesis.

Basic Information

Product Name	Spiro[Cyclopropane-1,3'-Pyrrolo[2,3-C]Pyridin]-2'(1'H)-One
CAS No.	1637752-28-3
Molecular Formula	C10H8N2O
Molecular Weight	172.18 g/mol
Synonyms	Spiro(cyclopropane-1,3'-pyrrolo[2,3-c]pyridin)-2'(1'H)-one; 1'H-Spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridin]-2'-one; Spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridin]-2'(1'H)-one; 1637752-28-3; SC-9188; Spirocyclopropane-pyrrolopyridinone; Pyrrolo[2,3-c]pyridine spirocyclopropane derivative
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,3'-Pyrrolo[2,3-C]Pyridin]-2'(1'H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity suitable for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.