Description

(R)-4-Fluoroindan-1-Amine Hydrochloride CAS NO 1637540-45-4 is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is of significant value for the research and development of novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and cardiovascular therapeutics. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the life sciences sector.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting neurological and cardiovascular pathways.
• Asymmetric Synthesis: Used as a chiral amine precursor or resolving agent in the preparation of enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated indane scaffold.
• Chemical Biology: Can serve as a building block for the development of molecular probes and enzyme inhibitors.
• Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-4-Fluoroindan-1-Amine Hydrochloride
CAS No.	1637540-45-4
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	(1R)-4-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride; (R)-4-Fluoroindan-1-amine HCl; (R)-1-Amino-4-fluoroindane hydrochloride; 4-Fluoro-(1R)-indan-1-amine hydrochloride; (R)-4-Fluoro-1-indanamine hydrochloride; (1R)-4-Fluoroindan-1-amine hydrochloride; (R)-1-(4-Fluorophenyl)ethylamine hydrochloride (related); 1637540-45-4
EINECS	Contact for details

Quality Control

Our (R)-4-Fluoroindan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.