Description

(R)-3-Fluoro-3-Methylpyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in the introduction of a fluorine atom and a methyl group onto the pyrrolidine scaffold, which can dramatically influence the metabolic stability, lipophilicity, and binding affinity of target molecules. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries engaged in the research and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore fluorinated analogs of bioactive molecules.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced, fluorinated pesticides and herbicides with enhanced properties.
• Asymmetric Synthesis: Employed as a chiral auxiliary or a resolved starting material in stereoselective catalytic reactions.
• Ligand and Catalyst Development: Utilized for constructing novel chiral ligands for metal-catalyzed transformations.
• Chemical Biology Probes: Incorporated into molecular probes to study biological processes and protein-ligand interactions.

Basic Information

Product Name	(R)-3-Fluoro-3-Methylpyrrolidine Hydrochloride
CAS No.	1637399-36-0
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(3R)-3-Fluoro-3-methylpyrrolidine hydrochloride; (R)-3-Fluoro-3-methylpyrrolidine HCl; (R)-3-Fluoro-3-methylpyrrolidinium chloride; 3-Fluoro-3-methylpyrrolidine hydrochloride (R-enantiomer); Pyrrolidine, 3-fluoro-3-methyl-, hydrochloride, (3R)-; (R)-3-Fluoro-3-methyl-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Fluoro-3-Methylpyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing full specifications, including enantiomeric excess (ee), is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (ee)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.