Description

1,1-Difluoro-5-Azaspiro[2.3]Hexane Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) where its scaffold can impart improved metabolic stability and bioavailability. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery for central nervous system (CNS), oncology, and other therapeutic areas.

Application

• Key Building Block in the synthesis of novel small molecule drug candidates.
• Medicinal Chemistry Research for exploring structure-activity relationships (SAR) in new chemical entities.
• Intermediate for the development of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Precursor in the manufacture of fluorinated heterocyclic compounds with potential biological activity.
• Used in process chemistry and route scouting for scale-up to GMP production.
• Research reagent in academic and institutional laboratories focused on organic and fluorine chemistry.

Basic Information

Product Name	1,1-Difluoro-5-Azaspiro[2.3]Hexane Hydrochloride
CAS No.	1630906-91-0
Molecular Formula	C6H9ClF2N
Molecular Weight	168.59 g/mol
Synonyms	5-Azaspiro[2.3]hexane, 1,1-difluoro-, hydrochloride; 1,1-Difluoro-5-azaspiro[2.3]hexane HCl; 1,1-Difluoro-5-azaspiro[2.3]hexane hydrochloride; 1,1-Difluoro-5-azaspiro[2.3]hexane monohydrochloride; 5-Azaspiro[2.3]hexane, 1,1-difluoro-, monohydrochloride; Difluorinated azaspirohexane hydrochloride; CAS 1630906-91-0
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-5-Azaspiro[2.3]Hexane Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports development from research to cGMP standards for advanced clinical trial material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.