Description

5-Bromo-3,3-Difluoro-1-Methyl-2,3-Dihydro-1H-Indol-2-One is a high-value, multi-functional heterocyclic building block characterized by its bromine and fluorine substituents, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for medicinal chemistry research and development, particularly in the synthesis of novel pharmaceutical candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor modulators, and other bioactive small molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced efficacy and environmental stability.
• Material Science: Serves as a precursor for functional dyes, organic semiconductors, and liquid crystals due to its conjugated indolone core.
• Chemical Biology: Employed as a probe or labeling agent in biochemical assays and diagnostic development.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex target compounds.
• Academic Research: A valuable reagent for methodological studies in organic synthesis, including cross-coupling and fluorination chemistry.

Basic Information

Product Name	5-Bromo-3,3-Difluoro-1-Methyl-2,3-Dihydro-1H-Indol-2-One
CAS No.	1630906-88-5
Molecular Formula	C9H6BrF2NO
Molecular Weight	262.05 g/mol
Synonyms	5-Bromo-3,3-difluoro-1-methylindolin-2-one; 2,3-Dihydro-5-bromo-3,3-difluoro-1-methyl-1H-indol-2-one; 5-Bromo-3,3-difluoro-1-methyl-2-indolinone; 1-Methyl-5-bromo-3,3-difluoroindolin-2-one; 5-Bromo-1-methyl-3,3-difluoro-2,3-dihydro-1H-indol-2-one; 5-Bromo-3,3-difluoro-N-methylisatin; CAS 1630906-88-5
EINECS	Contact for details

Quality Control

Our 5-Bromo-3,3-Difluoro-1-Methyl-2,3-Dihydro-1H-Indol-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.