Description

2,5-Diazaspiro[3.4]Octan-6-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR), particularly for compounds requiring a constrained spirocyclic amine moiety.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• CNS Drug Discovery: Employed in the research and development of therapeutics for neurological disorders due to the favorable physicochemical properties often associated with spirocyclic structures.
• Oncology Research: Utilized in the synthesis of potential kinase inhibitors or other oncology-focused small molecules.
• Chemical Biology Probes: Acts as a scaffold for creating tool compounds to study biological processes and validate novel drug targets.

Basic Information

Product Name	2,5-Diazaspiro[3.4]Octan-6-One Hydrochloride
CAS No.	1630906-86-3
Molecular Formula	C7H11N2O·HCl
Molecular Weight	176.63 g/mol
Synonyms	6-Oxo-2,5-diazaspiro[3.4]octane hydrochloride; 2,5-Diazaspiro[3.4]octan-6-one, hydrochloride; 2,5-Diazaspiro[3.4]octane-6-one HCl; Spiro[3.4]octane-6-one, 2,5-diaza-, hydrochloride; 1630906-86-3; 2,5-Diaza-spiro[3.4]octan-6-one hydrochloride
EINECS	Contact for details

Quality Control

Our 2,5-Diazaspiro[3.4]Octan-6-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.