Description

cis-3-Amino-1-Methylcyclobutanecarboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant building block featuring a constrained cyclobutane ring system. This compound is a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting neurological and metabolic disorders. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents.
• Peptidomimetics & Constrained Analogs: Used to introduce rigid, three-dimensional structural elements into peptide backbones to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Process Chemistry & Scale-up: Employed in the optimization and kilogram-scale production of candidate drugs during clinical development phases.
• Bioconjugation & Probe Development: The amino acid functionality allows for conjugation to fluorescent tags, biomarkers, or other molecular probes for biological studies.

Basic Information

Product Name	cis-3-Amino-1-Methylcyclobutanecarboxylic Acid Hydrochloride
CAS No.	1630906-61-4
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	(1R,3S)-3-Amino-1-methylcyclobutanecarboxylic acid hydrochloride; (1S,3R)-3-Amino-1-methylcyclobutanecarboxylic acid hydrochloride; 3-Amino-1-methylcyclobutanecarboxylic acid HCl; cis-1-Methyl-3-aminocyclobutanecarboxylic acid hydrochloride; 1-Methyl-3-aminocyclobutanecarboxylic acid hydrochloride; (cis)-3-Amino-1-methylcyclobutanecarboxylic acid hydrochloride; AMCBA hydrochloride; Cyclobutane amino acid derivative hydrochloride
EINECS	Contact for details

Quality Control

Our cis-3-Amino-1-Methylcyclobutanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.