Description

2-Azabicyclo[2.2.2]Octan-1-Ylmethanol Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique bridged bicyclic structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for neurological and central nervous system targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Neurological Drug Development: A crucial precursor for compounds targeting nicotinic acetylcholine receptors and related neurological pathways.
• Asymmetric Synthesis: Utilized as a scaffold or chiral auxiliary in stereoselective synthesis due to its rigid 3D structure.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme mechanisms and protein interactions.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis.

Basic Information

Product Name	2-Azabicyclo[2.2.2]Octan-1-Ylmethanol Hydrochloride
CAS No.	1630906-36-3
Molecular Formula	C8H16ClNO
Molecular Weight	177.67 g/mol
Synonyms	1-(Hydroxymethyl)-2-azabicyclo[2.2.2]octane hydrochloride; 2-Azabicyclo[2.2.2]octane-1-methanol hydrochloride; 2-Azabicyclo[2.2.2]octan-1-ylmethanol HCl; (2-Azabicyclo[2.2.2]octan-1-yl)methanol hydrochloride; ABCO-methanol hydrochloride; Quinuclidin-1-ylmethanol hydrochloride (related structure); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.2]Octan-1-Ylmethanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.