Description

1,1-Difluoro-5-Azaspiro[2.5]Octane Hydrochloride is a high-value, advanced pharmaceutical intermediate and building block characterized by its unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) seeking to incorporate fluorinated motifs for improved metabolic stability and bioavailability in drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the effects of fluorination and spirocyclic frameworks on drug-like properties.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) under GMP conditions.
• Fluorine Chemistry: An important reagent for introducing difluoromethylene groups into complex organic molecules, leveraging the unique properties of fluorine atoms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and methodology development.

Basic Information

Product Name	1,1-Difluoro-5-Azaspiro[2.5]Octane Hydrochloride
CAS No.	1630906-35-2
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	5-Azaspiro[2.5]octane, 1,1-difluoro-, hydrochloride; 1,1-Difluoro-5-azaspiro[2.5]octane HCl; 1,1-Difluoro-5-azaspiro[2.5]octane hydrochloride; 1,1-Difluoro-5-azaspiro[2.5]octane monohydrochloride; 5-Azaspiro[2.5]octane, 1,1-difluoro-, monohydrochloride; Difluorinated azaspirooctane hydrochloride; Spirocyclic difluoroamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-5-Azaspiro[2.5]Octane Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All materials are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, and our quality systems are designed to support development from research quantities through to cGMP commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.