Description

Venglustat is a potent and selective small molecule inhibitor of glucosylceramide synthase (GCS), a key enzyme in glycosphingolipid biosynthesis. This compound is of significant interest for its therapeutic potential in treating lysosomal storage disorders and other conditions linked to glycosphingolipid accumulation. It is primarily utilized by pharmaceutical research organizations and contract development and manufacturing organizations (CDMOs) engaged in the development of novel treatments for Gaucher disease, Parkinson's disease, and related disorders. Venglustat CAS NO 1629063-78-0 represents a critical advanced intermediate or active pharmaceutical ingredient (API) for clinical and pre-clinical studies.

Application

• Pharmaceutical API Intermediate: Serves as a key building block in the synthesis of the final active pharmaceutical ingredient for neurological and metabolic disorder treatments.
• Pre-clinical & Clinical Research: Used in laboratory studies and clinical trials to investigate the efficacy and safety of glucosylceramide synthase inhibition.
• Drug Discovery & Development: A vital reference standard and tool compound for medicinal chemistry programs targeting glycosphingolipid metabolism.
• Biochemical Research: Employed in vitro and in vivo to study the role of glucosylceramide and related lipids in cellular pathways and disease models.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for regulatory submissions.

Basic Information

Product Name	Venglustat
CAS No.	1629063-78-0
Molecular Formula	C₂₃H₂₈F₃N₃O₃
Molecular Weight	451.48 g/mol
Synonyms	SAR402671; GZ402671; (1S,2S,3R,4S,5R)-5-[4-(4-Fluorophenyl)-1H-imidazol-2-yl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol; 1,5-Anhydro-2,3,4-trideoxy-2-[4-(4-fluorophenyl)-1H-imidazol-2-yl]-D-arabino-hexitol; GCS Inhibitor; Glucosylceramide Synthase Inhibitor
EINECS	Contact for details

Quality Control

Our Venglustat is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development with materials that can meet the stringent requirements for cGMP compliance upon request, ensuring alignment with FDA and ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.