Description

2-(3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Acetic Acid is a specialized, high-value trifluoromethyl-diazirine functionalized building block. This compound is critical for advanced research and development, particularly in the field of photoaffinity labeling and chemical biology. It is primarily sought by pharmaceutical R&D teams, agrochemical innovators, and academic research institutions working on probe development and target identification. Its unique structure enables covalent cross-linking upon photoirradiation, making it an indispensable tool for studying biomolecular interactions.

Application

• Photoaffinity Labeling (PAL): A key reagent for creating photoactivatable probes to study protein-ligand interactions, enzyme active sites, and drug target engagement in live cells.
• Chemical Biology & Proteomics: Used to synthesize activity-based protein profiling (ABPP) probes for identifying and validating novel therapeutic targets.
• Pharmaceutical Research: Serves as a crucial intermediate in the discovery and development of new drug candidates, especially those targeting complex biological pathways.
• Agrochemical Development: Employed in the design of novel bioactive molecules with specific modes of action for crop protection.
• Bioconjugation: The carboxylic acid group allows for efficient conjugation to amines, alcohols, and other functional groups on biomolecules or solid supports.
• Material Science: Potential use in creating advanced polymeric materials with photo-responsive properties.

Basic Information

Product Name	2-(3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Acetic Acid
CAS No.	1627712-50-8
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	3-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzenacetic Acid; 2-[3-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]acetic Acid; (3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic Acid; TFD-Phenylacetic Acid; Diazirine-Phenylacetic Acid Derivative; Photoaffinity Labeling Reagent 1627712-50-8; Trifluoromethyldiazirine Benzoic Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Acetic Acid is manufactured and analyzed under strict quality protocols to ensure the high purity and consistency required for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to Off-White Solid
Identification (IR)	Conforms to Structure
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.