Description

1,4-Piperazinedicarboxylic Acid, 2-Methyl-, 1-[4-[(3-Chloro-2-Fluorophenyl)Amino]-7-Methoxy-6-Quinazolinyl] 4-(1,1-Dimethylethyl) Ester, (2R)- is a high-purity, advanced pharmaceutical intermediate with a complex, chiral molecular structure. This compound is critical for the synthesis of targeted therapeutic agents, offering researchers and manufacturers a reliable building block for complex molecular architectures. It is primarily utilized in the research and development of novel pharmaceutical compounds, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Oncology Drug Research: Used in the R&D of novel small-molecule inhibitors, particularly for kinase-targeted cancer treatments.
• Preclinical & Clinical Development: Supports drug discovery and development processes from lead optimization through to clinical trial material (CTM) production.
• Process Chemistry & Scale-Up: Provides a defined starting material for process development and the commercial-scale manufacturing of complex drug molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	1,4-Piperazinedicarboxylic Acid, 2-Methyl-, 1-[4-[(3-Chloro-2-Fluorophenyl)Amino]-7-Methoxy-6-Quinazolinyl] 4-(1,1-Dimethylethyl) Ester, (2R)-
CAS No.	1626387-95-8
Molecular Formula	C28H33ClFN5O5
Molecular Weight	574.04 g/mol
Synonyms	(2R)-1-(4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-methylpiperazine-1,4-dicarboxylic acid 4-tert-butyl ester; (2R)-1-[4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-methyl-1,4-piperazinedicarboxylic acid 4-(1,1-dimethylethyl) ester; 1,4-Piperazinedicarboxylic acid, 1-[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-methyl-, 4-(1,1-dimethylethyl) ester, (2R)-; CAS 1626387-95-8; Advanced Pharmaceutical Intermediate 1626387-95-8; Chiral Quinazoline Derivative.
EINECS	Contact for details

Quality Control

Our 1,4-Piperazinedicarboxylic Acid, 2-Methyl-, 1-[4-[(3-Chloro-2-Fluorophenyl)Amino]-7-Methoxy-6-Quinazolinyl] 4-(1,1-Dimethylethyl) Ester, (2R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.