Description

Methanesulfonato 2-Dicyclohexylphosphino-2-(N,N-Dimethylamino)biphenyl(2′-Amino-1,1′-biphenyl-2-yl) Palladium(II) is a highly active, air-stable palladium catalyst complex, specifically designed for Buchwald-Hartwig amination and other cross-coupling reactions. Its value lies in enabling efficient and selective C–N and C–C bond formation under mild conditions, which is critical for streamlining complex molecule synthesis. This catalyst is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries who require reliable and high-performance catalytic solutions.

Application

• Buchwald-Hartwig Amination: A premier catalyst for the coupling of amines with aryl halides, crucial for constructing pharmaceutical intermediates and active ingredients.
• Suzuki-Miyaura Cross-Coupling: Effective for the formation of biaryl structures, a common motif in drug discovery and material science.
• Academic & Industrial R&D: Serves as a key reagent in method development and discovery chemistry for novel compound libraries.
• Process Chemistry & Scale-Up: Used in the optimization and pilot-scale production of fine chemicals and APIs due to its stability and consistent performance.
• Synthesis of Heterocycles: Facilitates the construction of nitrogen-containing heterocyclic compounds, which are prevalent in medicinal chemistry.
• Material Science Research: Applied in the synthesis of conjugated polymers and organic electronic materials through efficient cross-coupling.

Basic Information

Product Name	Methanesulfonato 2-Dicyclohexylphosphino-2-(N,N-Dimethylamino)biphenyl(2′-Amino-1,1′-biphenyl-2-yl) Palladium(II)
CAS No.	1621274-13-2
Molecular Formula	C33H43N2O3PPdS
Molecular Weight	700.14 g/mol
Synonyms	Buchwald Palladium Precatalyst G4; Methanesulfonato(2-dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II); Pd-G4; Palladacycle G4; [2-(2-Aminobiphenyl)]Pd(MeCN)2OTs Analog; RuPhos Pd G4; AmPhos Pd G4; BrettPhos Pd G4; t-BuXPhos Pd G4
EINECS	Contact for details

Quality Control

Our catalyst is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and residual solvent levels is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Orange to brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Pd Content	14.0 - 16.0 %
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.