Description

Propan-2-Amine (S)-2-(((Benzyloxy)Carbonyl)Amino)-3,3-Dimethylbutanoate is a high-purity, chiral organic compound that serves as a critical building block in advanced synthetic chemistry. Its value lies in its role as a protected amino acid derivative, enabling the precise construction of complex peptide and small molecule targets. This intermediate is essential for research and development in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and proprietary APIs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce sterically hindered, non-proteinogenic amino acid residues.
• Protecting Group Strategy: The Cbz (Carboxybenzyl) protecting group on the amine functionality allows for selective deprotection in complex synthetic sequences.
• Asymmetric Synthesis: Employed in the development of chiral catalysts and ligands due to its defined stereochemistry at the α-carbon.
• Bioconjugation & Labeling: Useful for creating modified peptides for diagnostic and research applications.
• Academic & Industrial R&D: Serves as a valuable reference standard and starting material in medicinal chemistry and process development laboratories.

Basic Information

Product Name	Propan-2-Amine (S)-2-(((Benzyloxy)Carbonyl)Amino)-3,3-Dimethylbutanoate
CAS No.	1621085-33-3
Molecular Formula	C17H25NO4
Molecular Weight	307.39 g/mol
Synonyms	(S)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid propan-2-amine salt; Cbz-L-tert-Leucine Isopropylamine Salt; N-Carbobenzoxy-L-tert-leucine Isopropylamine Salt; Z-L-tert-Leucine · i-PrNH2; Nα-Cbz-L-tert-leucine isopropylamine salt; (2S)-2-[[(Phenylmethoxy)carbonyl]amino]-3,3-dimethyl-butanoic acid compound with propan-2-amine (1:1)
EINECS	Contact for details

Quality Control

Our Propan-2-Amine (S)-2-(((Benzyloxy)Carbonyl)Amino)-3,3-Dimethylbutanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.