Description

(S)-4,4-Difluoropiperidin-3-Ol Hydrochloride is a high-purity, chiral piperidine derivative of significant importance in modern pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas requiring fluorinated and stereochemically defined scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated piperidine core.
• API Development: Serves as a building block in the multi-step synthesis of complex, fluorinated active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for other enantiomerically pure compounds.
• Biochemical Tool Compound: Potential use in the development of biochemical probes and assay standards for pharmacological research.

Basic Information

Product Name	(S)-4,4-Difluoropiperidin-3-Ol Hydrochloride
CAS No.	1620656-05-4
Molecular Formula	C5H10F2NO • HCl
Molecular Weight	185.60 g/mol (Free base: 149.14 g/mol)
Synonyms	(3S)-4,4-Difluoro-3-piperidinol hydrochloride; (S)-4,4-Difluoro-3-hydroxypiperidine hydrochloride; (S)-4,4-Difluoropiperidin-3-ol HCl; 4,4-Difluoro-(3S)-piperidinol hydrochloride; (3S)-4,4-Difluoropiperidin-3-ol hydrochloride; (S)-3-Hydroxy-4,4-difluoropiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4,4-Difluoropiperidin-3-Ol Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP guidelines for non-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture uptake. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.