Description

Mpeg12-Br CAS NO 1620461-89-3 is a specialized monomethoxy polyethylene glycol (mPEG) derivative functionalized with a bromine (Br) group at the terminal position of a 12-unit PEG chain. This compound serves as a crucial versatile intermediate for chemical conjugation, enabling the attachment of the hydrophilic PEG spacer to various molecules to enhance solubility, reduce immunogenicity, and improve pharmacokinetic profiles. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing prodrugs, polymer-drug conjugates, and functionalized surfaces.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing antibody-drug conjugates (ADCs) and polymer-drug conjugates to improve drug delivery.
• Bioconjugation Linker: Used to PEGylate peptides, proteins, and oligonucleotides, enhancing their stability and circulatory half-life in vivo.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, and other material surfaces to impart stealth properties and biocompatibility.
• Prodrug Synthesis: Facilitates the creation of prodrugs where the active pharmaceutical ingredient (API) is released upon specific biological triggers.
• Polymer Chemistry: Acts as a macro-initiator or functional monomer in controlled radical polymerization techniques like ATRP (Atom Transfer Radical Polymerization).
• Cross-linking Agent: Used in the preparation of hydrogels and polymeric networks for biomedical applications such as tissue engineering.

Basic Information

Product Name	Mpeg12-Br
CAS No.	1620461-89-3
Molecular Formula	C27H55BrO13 (Typical for mPEG12-Br)
Molecular Weight	~667.6 g/mol (Theoretical)
Synonyms	mPEG12-Bromide; Bromo-PEG12-OMe; α-Methoxy-ω-bromo-poly(ethylene glycol) (12 EO units); 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatetracontan-37-yl Bromide; Monomethoxy Polyethylene Glycol Bromide (n=12); Br-PEG12-OCH3; PEG12 Methyl Ether Bromide
EINECS	Contact for details

Quality Control

Our Mpeg12-Br is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, functional group substitution, and impurity profiles. We adhere to relevant industry standards to support our customers in research, development, and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Complies
Assay (HPLC)	≥ 95%
Average Molecular Weight (GPC)	~660-680 Da
Moisture Content (KF)	≤ 1.0%
Bromine Content	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.