Description

(S)-5-Bromo-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine is a high-purity chiral building block of significant interest in advanced organic synthesis. Its value lies in the precise combination of a brominated pyrimidine core and a trifluoromethyl-substituted pyrrolidine moiety, which is crucial for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, oncology, and antiviral therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances bioavailability and metabolic stability.
• Ligand & Catalyst Development: Acts as a precursor for creating specialized ligands in asymmetric catalysis or for metal-organic frameworks (MOFs).
• Chemical Biology Probe Synthesis: Employed to build molecular probes for studying enzyme function and biological pathways.
• Material Science Precursor: Can be utilized in the synthesis of advanced organic electronic materials or liquid crystals.

Basic Information

Product Name	(S)-5-Bromo-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine
CAS No.	1620136-60-8
Molecular Formula	C9H9BrF3N3
Molecular Weight	296.09 g/mol
Synonyms	(S)-5-Bromo-2-[2-(trifluoromethyl)pyrrolidin-1-yl]pyrimidine; 1-[(S)-2-(Trifluoromethyl)pyrrolidin-1-yl]-5-bromopyrimidine; 5-Bromo-2-((S)-2-(trifluoromethyl)pyrrolidin-1-yl)pyrimidine; (S)-5-Bromo-2-(2-trifluoromethyl-1-pyrrolidinyl)pyrimidine; (S)-5-Bromo-2-(α,α,α-trifluoro-2-pyrrolidinyl)pyrimidine; (S)-1-(5-Bromopyrimidin-2-yl)-2-(trifluoromethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-5-Bromo-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.