Description

3-(Difluoromethoxy)Azetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1619991-11-5. This compound is valued for its unique azetidine scaffold and difluoromethoxy moiety, which are critical for modulating the pharmacokinetic and metabolic properties of active pharmaceutical ingredients. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel therapeutic agents and crop protection chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the difluoromethoxy group for enhanced biological activity and stability.
• Medicinal Chemistry: Serves as a versatile scaffold in drug discovery programs for creating novel compound libraries and probing structure-activity relationships (SAR).
• Chemical Synthesis: Employed in organic synthesis for the introduction of the azetidine ring, a valuable saturated heterocycle in modern medicinal chemistry.
• Process Development: Used in scale-up and process optimization studies for the commercial manufacturing of target molecules.

Basic Information

Product Name	3-(Difluoromethoxy)Azetidine Hydrochloride
CAS No.	1619991-11-5
Molecular Formula	C4H7F2NO•HCl
Molecular Weight	155.56 (Free base) / 192.02 (Hydrochloride)
Synonyms	Azetidine, 3-(difluoromethoxy)-, hydrochloride; 3-(Difluoromethoxy)azetidine HCl; 1-Azetidin-3-yloxy-difluoromethane hydrochloride; 3-(Difluoromethoxy)azetidine Hydrochloride Salt; 3-(Difluoromethoxy)azetidine HCl Salt; 3-O-(Difluoromethyl)azetidine hydrochloride; 1619991-11-5
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Azetidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.