Description

Benzyl-Peg8-Thp is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a benzyl group and a tetrahydropyranyl (THP) protecting group. This compound is engineered to serve as a versatile linker and spacer molecule in advanced chemical synthesis, offering controlled reactivity and solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing prodrugs, antibody-drug conjugates (ADCs), and other complex therapeutic agents.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of prodrugs and targeted drug delivery systems, facilitating controlled release.
• Bioconjugation Spacer: Used to attach therapeutic payloads (e.g., cytotoxins) to antibodies, proteins, or peptides in ADC development, improving solubility and pharmacokinetics.
• Polymer Chemistry Building Block: Serves as a functional initiator or monomer for creating tailored PEG-based polymers and hydrogels with specific end-group functionality.
• Material Science: Employed in surface modification and the creation of functional coatings to alter material properties like hydrophilicity and biocompatibility.
• Chemical Synthesis Intermediate: The THP protecting group allows for selective reactions, making it valuable in multi-step organic synthesis for complex molecules.
• Research & Development: A critical reagent in academic and industrial R&D for exploring new drug delivery modalities and biomaterials.

Basic Information

Product Name	Benzyl-Peg8-Thp
CAS No.	1611489-00-9
Molecular Formula	C34H60O11
Molecular Weight	644.8 g/mol
Synonyms	1-Benzyl-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-ol, 27-(Tetrahydro-2H-pyran-2-yloxy)-; Benzyl tetraethylene glycol THP ether (PEG8 variant); Benzyl-PEG8-THP ether; 2-[2-[2-[2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxymethyl tetrahydro-2H-pyran; THP-PEG8-O-Benzyl; Bn-PEG8-THP; Benzyl octaethylene glycol THP ether
EINECS	Contact for details

Quality Control

Our Benzyl-Peg8-Thp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with precise specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is sensitive to strong acids and organic solvents; keep away from incompatible substances. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.