Description

Otbu-Peg3-Otbu is a high-purity, bifunctional PEG-based linker and chemical building block. This compound is essential for researchers and manufacturers requiring a precisely defined, short polyethylene glycol (PEG) spacer with orthogonal protecting groups. It is primarily utilized in the synthesis of complex molecules, including bioconjugates, PROTACs, and advanced pharmaceutical intermediates, where controlled spacing and solubility are critical. The product is supplied under the CAS registry number 1611468-29-1.

Application

• PROTAC (Proteolysis Targeting Chimera) Linker: Serves as a crucial component to connect the E3 ligase ligand and the target protein ligand, providing optimal length and flexibility for ternary complex formation.
• Bioconjugation & ADC Development: Acts as a hydrophilic spacer to connect payloads (e.g., toxins, dyes, drugs) to antibodies, proteins, or peptides, improving solubility and pharmacokinetic properties.
• Chemical Biology Probes: Used to synthesize probes for studying protein-protein interactions, cellular localization, and other biological processes.
• Polymer & Material Science: A versatile monomer or cross-linker for creating functionalized hydrogels, smart materials, and surface coatings with tailored properties.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) and candidates for drug discovery programs.
• Peptide & Oligonucleotide Modification: Enables site-specific PEGylation to enhance the stability, bioavailability, and circulation half-life of therapeutic biomolecules.

Basic Information

Product Name	Otbu-Peg3-Otbu
CAS No.	1611468-29-1
Molecular Formula	C18H38O6
Molecular Weight	350.50 g/mol
Synonyms	1,11-Bis(tert-butoxy)-3,6,9-trioxaundecane; 2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-ol) ditert-butyl ether; tert-Butyl-PEG3-OTB; Di-tert-butyl PEG3; 3,6,9-Trioxaundecane-1,11-diyl bis(2-methyl-2-propanoate); PEG3-di-OtBu; 1,11-Di-O-tert-butyl-triethyleneglycol; OTB-PEG3-OTB
EINECS	Contact for details

Quality Control

Our Otbu-Peg3-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO standards ensures a reliable supply for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.