Description

[4-[[(2S)-2-[[(2S)-2-Amino-3-Methylbutanoyl]Amino]-5-(Carbamoylamino)Pentanoyl]Amino]Phenyl]Methyl n-[2-(Pyridin-2-Yldisulfanyl)Ethyl]Carbamate is a sophisticated synthetic peptide derivative featuring a cleavable disulfide linker, designed for advanced bioconjugation and targeted drug delivery applications. Its core value lies in enabling the precise attachment of therapeutic or diagnostic payloads to targeting molecules, such as antibodies, through a reversible linkage that can be cleaved under specific biological conditions. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors working on antibody-drug conjugates (ADCs), targeted therapies, and advanced diagnostic probes.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload: Serves as a key intermediate for constructing ADCs, where the disulfide bond provides a mechanism for controlled drug release within target cells.
• Bioconjugation Reagent: Used to covalently link peptides, proteins, or other biomolecules to drugs, dyes, or solid supports for targeted delivery or diagnostic applications.
• Prodrug Development: Acts as a component in prodrug strategies, where the active pharmaceutical ingredient is masked by the linker and released upon exposure to reducing environments like the intracellular space.
• Research Tool in Chemical Biology: Employed in studies exploring protein-protein interactions, cell signaling pathways, and the development of novel therapeutic modalities that require site-specific conjugation.
• Diagnostic Agent Conjugation: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting vectors for in vitro and in vivo diagnostics.

Basic Information

Product Name	[4-[[(2S)-2-[[(2S)-2-Amino-3-Methylbutanoyl]Amino]-5-(Carbamoylamino)Pentanoyl]Amino]Phenyl]Methyl n-[2-(Pyridin-2-Yldisulfanyl)Ethyl]Carbamate
CAS No.	1610769-13-5
Molecular Formula	C27H37N7O6S2
Molecular Weight	619.75 g/mol
Synonyms	Pyridyl Disulfide Val-Cit-PAB Carbamate; Disulfide-Linked ADC Linker; Valine-Citrulline-PAB-Pyridyl Disulfide; VC-PAB-PySS; N-[2-(Pyridin-2-yldisulfanyl)ethyl]carbamic acid 4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]phenylmethyl ester; Cleavable Peptide Linker; ADC Linker-Payload Intermediate; (S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanoic acid 4-((((2-(pyridin-2-yldisulfanyl)ethyl)carbamoyl)oxy)methyl)phenyl ester
EINECS	Contact for details

Quality Control

Our [4-[[(2S)-2-[[(2S)-2-Amino-3-Methylbutanoyl]Amino]-5-(Carbamoylamino)Pentanoyl]Amino]Phenyl]Methyl n-[2-(Pyridin-2-Yldisulfanyl)Ethyl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development under cGMP conditions where required, ensuring compliance with rigorous industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Disulfide Bond Integrity (HPLC)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.