Description

Tco-Nh2, Hcl Salt is a protected amino acid derivative, specifically the hydrochloride salt of an amino acid bearing a tert-butyloxycarbonyl (Tco) protecting group. This compound is a crucial building block in modern peptide synthesis and medicinal chemistry, enabling the controlled assembly of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids in automated peptide synthesizers.
• Medicinal Chemistry & Drug Discovery: Serves as a protected precursor for constructing peptide-based drug candidates, prodrugs, and targeted conjugates.
• Bioconjugation: Used to introduce specific amino acid functionalities into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Chemical Biology Research: Essential for synthesizing custom peptides used as probes, inhibitors, or substrates in biochemical assays.
• Combinatorial Library Synthesis: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• API Intermediate Production: Acts as a critical raw material in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) with peptide motifs.

Basic Information

Product Name	Tco-Nh2, Hcl Salt
CAS No.	1609659-02-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	tert-Butyloxycarbonyl-protected Amino Acid Hydrochloride; Boc-Amino Acid·HCl; N-(tert-Butoxycarbonyl)amino acid hydrochloride; BOC-NH-CHR-COOH·HCl; Amino acid, N-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride; Tco-AA-OH·HCl; Protected amino acid HCl salt; BOC-AA-HCl
EINECS	Contact for details

Quality Control

Our Tco-Nh2, Hcl Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.