Description

Methanesulfonato[4,6-Bis(Diphenylphosphino)Phenoxazine](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(Ii) is a highly specialized, air-stable palladium(II) pre-catalyst featuring a unique phenoxazine-based ligand system. This compound matters for its exceptional performance in challenging cross-coupling reactions, offering superior activity and selectivity under mild conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing complex organic molecules.

Application

• Buchwald-Hartwig Amination: A premier catalyst for C–N bond formation, especially for coupling sterically hindered or electronically deactivated aryl halides with amines.
• Suzuki-Miyaura Cross-Coupling: Effective for constructing biaryl and heterobiaryl structures, crucial in pharmaceutical and material science intermediates.
• C–O and C–S Bond Forming Reactions: Enables the coupling of aryl halides with phenols, thiols, and related nucleophiles.
• Pharmaceutical Intermediate Synthesis: Key for constructing active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-amine linkages.
• Ligand Screening & Catalyst Development: Serves as a benchmark or starting point for developing new catalytic systems in academic and industrial research.
• Material Science: Facilitates the synthesis of conjugated polymers and organic electronic materials through efficient cross-coupling.

Basic Information

Product Name	Methanesulfonato[4,6-Bis(Diphenylphosphino)Phenoxazine](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(Ii)
CAS No.	1602922-03-1
Molecular Formula	C55H46N2O4P2PdS
Molecular Weight	1003.36 g/mol
Synonyms	Palladium(II) methanesulfonate complex with 4,6-bis(diphenylphosphino)phenoxazine and 2'-amino-1,1'-biphenyl-2-yl; [Pd(Amphos)(Biaryl-amine)]OMs; Buchwald Palladium Precatalyst G4; Pd-Phenoxazine Precatalyst; (2'-Amino[1,1'-biphenyl]-2-yl)palladium(II) methanesulfonate complex with 4,6-bis(diphenylphosphino)phenoxazine; CAS 1602922-03-1
EINECS	Contact for details

Quality Control

Every batch of our palladium catalysts undergoes rigorous quality testing to ensure high catalytic activity, lot-to-lot consistency, and purity. Our standard quality commitment includes comprehensive analysis via NMR, HPLC, and elemental analysis. Certificates of Analysis (COA) detailing identity, purity, and residual solvent content are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen), as it is easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Palladium (Pd) Content	10.0 - 11.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.